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More importantly, this pro-inflammatory oxidative environment alters astrocytic physiological states, potentially impairing their ability to form TNTs or generate EVs, thereby directly inhibiting mitochondrial transfer mechanisms

Moreover, inhibition of mGluR5 was shown to enhance the potency of chemotherapeutic agents in hepatocellular carcinoma cell lines and attenuate chemotoxicity over DNA damage by downregulating Ca 2+ -dependent MAPK signaling in the normal liver (76)