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On another side, the RNS, mainly the peroxynitrite (ONOO ) interact with guanine to generate oxidative and nitrative DNA damage such as 8-oxodeoxyguanosine and 8-nitroguanine, respectively (Phaniendra et al., 2015)

Optimizing backing layers can also address these challenges

Therefore, it is recommended to use a comprehensive assessment system that integrates respiratory mechanics parameters (such as airway resistance and pulmonary compliance), oxygenation indices (PaO2/FiO2), and psychological status evaluation scales

doi: 10.1016/j.biopha.2023.114333 39 LiBWangCLuPJiYWangXLiuCet al

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