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However, MASLD patients often display an increased gut permeability and intestinal dysbiosis that leads to portal circulation of gut-derived toxins and hepatic inflammation [32]

Italian working group on endocrine complications in non-endocrine diseases

However, NLRP3 and IL-1 were found in active UC, a neutrophil-dominated lamina propria cell population, indicating that IL-1 is processed independently of the inflammasome (91)

Worryingly, the best performing ANA ELISA contained amongst its nuclear target antigens also the mitochondrial M2 antigen, questioning the validity of the assay in the detection of ANA