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Int J Biochem Cell Biol 37:24662471 OConnell KE, Mikkola AM, Stepanek AM, Vernet A, Hall CD, Sun CC, Yildirim E, Staropoli JF, Lee JT, Brown DE (2015) Practical murine hematopathology: a comparative review and implications for research

Among the 52 patients treated, the ORR was 11%, the disease control rate was 76%, median OS was 9.5 months, and some responses, regarding systemic disease control, persisted beyond 23 months despite the heavily pretreated cohort (115)

Alternatively, Th2 cells response is rather associated with non-protective immunity through the activation of M2 macrophages and decrease of Th1 response (110, 113)