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Description

These outcomes were accompanied by the restoration of neurotransmitter balance, particularly the enhancement of GABAergic inhibition and the reduction of excessive glutamatergic excitation

Elghaba, R

In the SURMOUNT-5 trial (NEJM, 2025), tirzepatide reduced body weight by 20.2% versus 13.7% for semaglutide over 72 weeks

doi: 10.1007/s40265-024-02134-0 129 GaoA.KouznetsovaV

and components of the pyruvate dehydrogenase (PDH) complexdihydrolipoamide S-acetyltransferase (DLAT), pyruvate dehydrogenase E1 subunit 1 (PDHA1), and pyruvate dehydrogenase E1 subunit (PDHB) (Figure 2) (Tsvetkov et al., 2022)