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Policy Note: This article is a slightly abridged version of a review first published in the Cleveland Clinic Journal of Medicine (2025;92(3):147-151)

MB upregulates the expression of Nrf2 and its downstream antioxidant genes The nuclear factor erythroid 2-related factor 2 (Nrf2) is known as an essential regulator of antioxidant defense system by inducing the expression of an array of antioxidant response element (ARE)-containing genes, thereby decreasing overall cellular ROS 22

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Long-Term Survival Outcomes of Cytoreductive Nephrectomy Combined with Targeted Therapy for Metastatic Renal Cell Carcinoma: A Systematic Review and Individual Patient Data Meta-Analysis