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However, its clinical translation is severely hindered by poor aqueous solubility, rapid metabolism, and negligible oral bioavailability (typically 99% of reported delivery platforms [13]

Anti-inflammatory mechanisms Inflammation exacerbation is one of the characteristics of a series of diseases, including cardiovascular disease, diabetes, metabolic syndrome, rheumatoid arthritis, asthma, multiple sclerosis, and chronic pain, each of which would increase the risk of depression (Dantzer et al., 2008

Consistent with a transport-independent function for GLUT3 in IL-4 signal transduction, the activation of p-STAT6 by IL-4 was not impaired in THP-1 cells treated with G3iA (Figure 4F and Supplemental Figure 7G)

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Moreover, the expression of phosphatases can be affected by oxidative stress [58]