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It is important to mention that in assessing platelets in MS patients, increased activity of free radicals with decreased levels of important antioxidants such as glutathione and alphatocopherol has been reported [7] (Figure 2)

[Note: Flavin mononucleotide, flavin adenine dinucleotide, heme, and tetrahydrobiopterin are additional coenzymes required by NOS.] 2

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J Crit Care 29:883.e7883.e11 Chelkeba L, Ahmadi A, Abdollahi M et al (2015) The effect of parenteral selenium on outcomes of mechanically ventilated patients following sepsis: a prospective randomized clinical trial