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Between-group comparisons showed that the percentage of patients who experienced worsening of depressive symptoms was significantly different between the CBT-I + CRS group and the nontreated and CRS groups

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Hence, cysteine modifications are not limited to the well-known structural role of disulfide bonds in proteins synthesized in the endoplasmic reticulum (ER), but participate in fundamental intra- and inter-cellular signaling pathways