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5.3.8 Inhibition of angiogenesis Dihydroartemisinin inhibited tumor vascularization by decreasing the expression of HIF-1, VEGF, and endothelial cell-specific marker (CD31 and NG2) proteins, leading to a significant reduction in microvessel and mature vessel density in a time-dependent manner (Zhang et al., 2013)

For example, modulation of p21, p27, cyclins D1/E, and CDKs 2/4 contributes to checkpoint arrest and facilitates apoptotic signaling (29)

Attention is also paid to the effect of antioxidants to alleviate the level of oxidative stress, which is a common denominator of various chronic diseases such as neurological disorders, cancer, cardiovascular, renal, lung, metabolic, neurological, psychiatric, and other diseases

And it is important to note: benefits largely reverse when treatment is stopped, pointing toward long-term use as the more effective strategy for sustained PMOS management