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Iron metabolism and ferroptosis may induce neurological damage through interactions with the central nervous system, gut microbiota, and brain-gut axis, positioning them as potential therapeutic targets for depression (Figure 3)

Notch pathway activity varies across tumor regions, with higher expression in peritumoral GSCs than in the tumor core, suggesting a role in maintaining stemness and therapeutic resistance

Gwak SJ, Yun Y, Yoon DH, Kim KN, Ha Y (2016) Therapeutic use of 3beta-[N-(N, N-dimethylaminoethane) carbamoyl] cholesterol-modified PLGA nanospheres as gene delivery vehicles for spinal cord injury