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Brain homogenates were centrifuged at 10,000 g for 10 min at 4C

Patients affected by methylmalonic aciduria show cognitive impairment, and in mice, MMA accumulation in the brain causes neuroinflammation and oxidative stress injury (34)

One aspect of the invention pertains to the administration of one or more NNMT inhibitors by, for example, contacting one or more cells of an animal to: muscular disorders including, but not limited to, sarcopenia, muscle atrophy, Duchenne muscular dystrophy, Becker muscular dystrophy, Limb-girdle muscular dystrophies, Pompe disease, cardiac myopathies, pulmonary disorders

Moreover, compound 8 showed good oral bioavailability and good half life and moderate plasma clearance and volume distribution

The ruthenium(II)arene compound RAPTA-C induces apoptosis in EAC cells through mitochondrial and p53JNK pathways