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doi: 10.3389/fbioe.2024.1371596 331 ParkA

This difference in efficiency is in line with the improved cellular uptake of phenformin over metformin and the much lower typical therapeutic dosage of phenformin compared to metformin in humans 68

This approach significantly enhances the magnitude and specificity of immune responses and offers a powerful strategy to overcome multiple limitations associated with conventional immunotherapies (Xin et al., 2025