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Shown in Supplementary Tables 10 and 11 and Supplementary Tables 1419 are top 20 up- and downregulated genes in response to siRNA and drug treatments

This toxin, botulinum, can help treat various health problems , but also for cosmetic reasons such as reducing wrinkles

Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P, et al

10.1016/j.canlet.2017.03.029 86

it remains a dietary supplement, not a drug Clinical trials (Phase I/II) have primarily assessed safety, dosing, and biomarker modulation rather than definitive efficacy endpoints