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Then, miR-149-5p was overexpressed in MSCs by lentiviral packaging system to generate the desired exosomes

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Damage dermal fibroblasts the cells responsible for producing collagen, elastin, and the extracellular matrix that gives skin its structural integrity

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Additionally, SF (5.64 mol/kg/day for 15 days) demonstrated therapeutic effects in a rat model induced with nicotinamide and streptozotocin by restoring insulin levels, normalizing motor coordination, improving sensory responses, and ameliorating histopathological changes (123)

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