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When to Consider Switching to Tirzepatide or Combination Therapy If dose escalation within semaglutide does not restore progress, tirzepatide offers a mechanistic advantage: it activates both GLP-1 and GIP receptors, engaging a broader appetite-suppression network

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Xie L, Chen W, Chen Q, Jiang Y, Song E, Zhu X, et al

The 20mg dose tended to exhibit no significantly a slightly greater reduction in ALT levels than the 10mg dose

doi: 10.1016/j.jcmgh.2016.06.004