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However, enhanced DNA repair capacity can provide resistance by efficiently repairing drug-induced DNA damages via the activation of repair pathways such as nucleotide excision repair and homologous recombination ( Cell death inhibition: Cancer cells can develop a variety of ways to avoid chemotherapy-induced cell death, allowing them to survive and proliferate

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The significantly elevated GSSG/GSH and NADP + /NADPH ratios of the control cell line indicated that the cells were unable to effectively regulate the excessive oxidative stress triggered by viral replication, and the oxidative and antioxidant effects were imbalanced in vivo, with the cells favoring the oxidative state

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Padua RA, Sarda-Mantel L, Chiquet M, Kappel C, Krief P, Setterblad N, Hontonnou F, Hosten B, Vignal N, Zassadowski F, Cassinat B, Gou P, Giraudier S, Konopleva MY, Andreeff M , PLA M, Ades L, Fenaux P, Chomienne C