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Molecules administered by intrathecal administration still encounter barriers within the subarachnoid space for drug penetration from CSF into brain parenchyma, but IT dosing creates a favorable concentration gradient for drugs to diffuse

Digesting the impact of diet on irritable bowel syndrome (IBS): exploring solutions for controlling IBS

For instance, Chikwanha et al

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In another study involving Type 2 Diabetes patients, the consumption of milk kefir consisting of Lactobacillus acidophilus , Lactococcus casei , Streptococcus thermophilus , and Bifidobacterium lactis for two months showed a 2.12-fold decrease in Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), which is clinically relevant as it suggests an improvement in insulin sensitivity and potentially can prevent a sudden spike in blood sugar level (Alihosseini et al., 2017)