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280 Furthermore, activation of the inflammation-related NLRP3 inflammasome signaling pathway in different types of neural cells was closely associated with high cholesterol load, which triggered neuroprotective properties in activated microglia but promoted oxidative stress in neurons, further enhancing the expression of NLRP3 inflammasomes, inducing neuronal pyroptosis, and impairing the phagocytic capacity of microglia

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doi:10.1016/j.ejphar.2015.11.048 Tan SW, Israf Ali DAB, Khaza'ai H, Wong JW, Vidyadaran S

Phase I dose-escalation trial of MIW815 (ADU-S100), an intratumoral STING agonist, in patients with advanced/metastatic solid tumors or lymphomas

Some of these spherical granular structures contain a patched meshwork-like border of single discontinuous filaments at the periphery, and a few disorganized short loose intermediate filaments inside (Supplementary Fig