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Medicines which can decrease the absorption of Vitamin B12 include: Colchicine (a medicine used to treat gout) Metformin (an anti-diabetic agent) Excessive Alcohol Vitamin C products

Genetic research is identifying polymorphisms that predict superior response to the combination therapy

This is due to the possibility that more glycine and serine may be needed to properly catabolize the extra methionine, unintentionally leading to a shortage in these amino acids