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HK2 interacts with nuclear proteins such as Max, Sirt1, IWS1, CTR9, and Spin1, increasing chromatin accessibility to regulate gene expression

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Dermatological Reviews, 7(2), e70067

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The peptidomimetic design often incorporates D-amino acids or non-natural backbones to resist enzymatic breakdown, extending its circulation time in the blood to allow for "homing" to adipose tissue