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JCI Insight 6 , e14457 (2021)

This mechanism makes L-carnitine especially valuable during aerobic exercise, when the body taps into fat stores for sustained energy

346,347,348 The first is the exogenous route, in which the NADs are directly introduced into the obtained exosomes via electroporation, co-incubation, sonication, extrusion, and freeze-thaw cycling

Emerging evidence further expands this mechanistic landscape

The needles create temporary channels through the stratum corneum while the serum flows through the needle bore at the same time, bypassing the skin barrier that would otherwise block large molecules like peptides, growth factors, and high-molecular-weight hyaluronic acid