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Furthermore, accumulating evidence has shown that NNMT knockdown significantly decreases tumorigenesis and chemoresistance capacity

The realization of T2D as downstream disease of MDS suggests that metabolic complications or MDS-related TOD may be more reasonable instead of so-called chronic diabetic complications

Figure 7 Current research on ferroptosis in kidney diseases has predominantly focused on AKI and CKD, with accumulating evidence linking ferroptosis to interstitial fibrosis, mitochondrial dysfunction, inflammatory cell infiltration, and impaired tubular regeneration, key drivers of CKD progression (285, 286)

Thus, the mechanisms of MDD development involve the interaction of many components of biological origin, including the microbiota and gut-brain axis

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