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However, clinical trials investigating these pathways, are subject to limitations including the heterogeneity in TBI severity/etiology, variations in experimental time points and the methods applied to measure metabolites

As a result, the residual H 2 O 2 levels may not be sufficient to significantly modulate catalase expression, which could explain the unchanged catalase levels observed following ALA treatment

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The pain was described as constant with episodic worsening, beginning with a rash in the right upper quadrant