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It is not elegant, but it works

moreover, in the literature there are no reports on Petronie's disease resistant to medical therapy, which constitutes a class destined to remain unhealed, where even surgery is not a feasible proposition (reserved exclusively for those subjects in whom progression of the disease has been arrested by medical therapy) and no wholly reliable pharmacological therapy is yet available

As such, the known information suggests that epigenetic reprogramming may contribute to the phenotypic transformation of immune cells and favor the development of NAFLD by influencing their inflammatory environment [54, 55]