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Beyond the bench-to-bedside gap, another critical challenge arises from the limited biological diversity represented in preclinical models

In another study, vemurafenib-loaded lipid nanocomplexes in melanoma model revealed downregulation of Ki-67 and BRD4 and significant tumor necrosis [133]

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Human data is thinner and mostly based on precursors, not liposomal NAD+ directly

1d) across class-defining, risk-modifying and MDS-related genetic aberrations were similar to previous studies 24,25 (Fig