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Rating: 4.801 (13 reviews)

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Wang X, Mak PY, Mu H, Jian X, Mak D, Pachter JA, Weaver DT, XU B, Andreeff M , Carter BZ

Pigmentation Reduction: In the body, the melanin pigment is produced by melanocytes (type of skin cells)

Plumbagin exhibits genotoxicity and induces G2/M cell cycle arrest via ROS-Mediated oxidative stress and activation of ATM-p53 signaling pathway in hepatocellular cells

In addition, mitochondria contribute to drug resistance mechanisms in cancer cells in several ways, including modulation of apoptosis, alteration of reactive oxygen species (ROS) levels, and regulation of drug efflux pumps (30, 31)

A Kaplan-Meier survival curve investigation of PD-L1 expression with mortality indicated that glioma patients with higher PD-L1 expression had poorer survival outcomes (Supplementary Fig