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The AMPK modulator metformin as adjunct to methotrexate in patients with rheumatoid arthritis: A proof-of-concept, randomized, double-blind, placebo-controlled trial

To mitigate placebo effects, crossover designs with washout periods (e.g., 4 weeks) are advantageous

Aortic dissection, also known as an aortic dissection aneurysm, is a serious cardiovascular emergency

Khatib TZ, Osborne A, Yang S, Ali Z, Jia W, Manyakin I, et al

The reduction in hypogonadic patients of Prosaposin (PSAP), Ropporin-1B (ROPN1B), Plasma serine protease inhibitor (SERPINA5) and SPARC-related modular calcium-binding protein 1 (SMOC-1) might, in fact, reflect a dysregulation of the molecular machinery involved in spermiogenesis ( The increase of 5-oxoprolinase (OPLAH) in hypogonadism might reflect a deficiency in the biosynthesis of glutathione, which is an important scavenger for reactive oxygen species in man ( Moreover, we observed that male hypogonadism may impact sperm motility through the down-regulation of some specific proteins such as A-kinase anchor protein 3 (AKAP3), A-kinase anchor protein 4 (AKAP4), Hydrocephalus-inducing protein homolog (HYDIN) and ROPN1B, which are constitutive of the microtubule ( Furthermore, -Microseminoprotein (MSMB) and Protein S100-A8 (S100A8) were reduced in sperm samples of hypogonadic patients