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The molecular basis of adrenal resistance to ACTH includes defects in ligand binding, MC2R/MRAP receptor trafficking, cellular redox balance, cholesterol synthesis, and sphingolipid metabolism

(9) Rotondi and colleagues have determined that seronegative autoimmune thyroiditis is a less aggressive form of Hashimotos, but nonetheless, the person may still develop hypothyroidism and even progress to other autoimmune conditions, which may or may not have respective positive antibody blood markers (such as seronegative rheumatoid arthritis)

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