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Description

A pivotal 2009 study published in Neuro Endocrinology Letters by Maes et al

Was the outcome clinically meaningful

Trimethoprim is metabolized in vitro to 11 different metabolites, of which, five are glutathione adducts and six are oxidative metabolites, including the major metabolites, 1- and 3-oxides and the 3- and 4hydroxy derivatives

The synthesis and agglutination of melanin happen due to the reaction of Tyrosinase enzymes and L-DOPA that oxidize your skin to cause melanin synthesis