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In neurodegenerative diseases, ferroptosis may play a role by affecting oxidative stress in neurons and mitochondrial function

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Indian J Dermatol 27(2):60-2, 1982

Neural Regen Res 15:12201234

As one of the rate-limiting substrates for the synthesis of GSH, which maintains redox balance, Cys availability and GSH levels jointly influence ROS stress and the extent of inflammatory signal amplification, thereby indirectly shaping the pro-inflammatory or reparative functional spectrum ( 2 S), which, as a gaseous signaling molecule, can regulate multiple inflammation-related pathways and affect macrophage phenotypes (7477)