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Based on these conflicted results, the association was speculated to be related to the clinical features of the population, stages of the disease, severity of copper excess, and types of detected specimens in these studies (Table 1)

Registration of a novel indication for amlodipine in the future would be a therapeutic breakthrough, particularly for people with diabetes and cardiovascular problems

Contradictory results again show a mixed treatment effect with some studies favoring combined therapy, while others show no additional benefit compared to systemic therapy alone [98, 118,119,120,121,122]

Theres no pharmacological interaction

Neuropathy and related findings in the diabetes control and complications trial/epidemiology of diabetes interventions and complications study