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While these diseases have distinct etiologies and pathologies, they all involve neuronal loss and sustained activation of the brains immune system, including microglia and astrocytes (Ferreira et al., 2013)

Molecules (Basel, Switzerland), 19(11), 1906619077

Science 350 (6265), 12141215

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MOTS-c modulates the FOXO transcription factors and regulates cellular senescence, the state in which aged or damaged cells stop dividing but refuse to die, instead secreting a cocktail of inflammatory signals known as the senescence-associated secretory phenotype (SASP)