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Vo TTT, Peng TY, Nguyen TH, Bui TNH, Wang CS, Lee WJ et al (2024) The crosstalk between copper-induced oxidative stress and cuproptosis: a novel potential anticancer paradigm

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Encouragingly, 2 randomized phase 2 trials are currently ongoing in pancreatic (NCT02905578) [137] and prostate (NCT02516670) [140] cancer patients, directly comparing the added benefit of high-dose IVC to standard chemotherapy

Free SH groups, as in reduced GSH, are essential for the activity of all metabolite carriers in the inner mitochondrial membrane, otherwise, extensive thiol oxidation results in: the inhibition of transport activity, and the dissipation of the mitochondrial inner transmembrane potential ([]), an early, potentially reversible event observed in mitochondrial related apoptotic processes, bioenergetic failure, also an early event that is part of the dissipation of [], and an increase in the permeability of the mitochondrial membrane, a later event in mitochondrial related apoptotic processes

Such an extrapolation based solely on laboratory-defined hazard is the usual situation faced by the toxicologist, occupational health specialist and regulator in dealing with a new substance