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In patients with constipation, abnormal distension can contribute to pain

Both peripheral immune responses and local tissue responses are disrupted under heat stress

Native peptide drugs, however, are generally ineffective when given orally due to low oral bioavailability, which is as a result of the physical and biochemical barriers of the gastrointestinal tract (GIT), often forcing the use of invasive parental delivery methods that lead to low patient compliance [3,4]

This suggests that miR-192-5p serves as a protective regulator against hepatic steatosis in MASLD by modulating the SCD-1 and Yy1/FAS signaling pathways