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When ROS levels exceed those of antioxidant defenses, there is an aberrant increase in free radical generation resulting in mitochondrial damage and leading to oxidative stress and subsequently this increased stress can reduce ETC activity (Gu et al., 2013) (Figure 2)

[DOI] [PubMed] [Google Scholar] 90.De la Fuente M, Hernanz A, Vallejo MC

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In summary, the absence of GR markedly attenuated the virulence of Av

Most ASMs that are presently available seek to target seizures rather than epilepsy pathophysiology, and they work by decreasing neuronal excitability