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scavenges superoxide anion Anti-proliferative effect - inhibits smooth muscle hyperplasia Because of the above actions of NO, when its production is impaired or its bioavailability is reduced, the following can result: Vasoconstriction (e.g., coronary vasospasm, elevated systemic vascular resistance, hypertension) Thrombosis because of platelet aggregation and adhesion to vascular endothelium Inflammation because of upregulation of leukocyte and endothelial adhesion molecules Vascular hypertrophy and stenosis Diseases or Conditions Associated with Abnormal NO Production and Bioavailability Hypertension Obesity Dyslipidemias (particularly hypercholesterolemia and hypertriglyceridemia) Diabetes (both type I and II) Heart failure Atherosclerosis Aging Cigarette smoking Revised 01/05/2018

TIMING AND OTHER CONSIDERATIONS Aspiration of the olecranon bursa may be performed acutely for relief of swelling and discomfort

Chem., 2004, 43, 36953699

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