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Pinna et al

This is a technology that we have been pioneering for more than 20 years, said Jeon Woong Kang, Ph.D., research scientist with MITs Laser Biomedical Research Center and co-author of the study

Methods: To address this, we have developed a protocol for transforming human primary hepatocytes into expandable Hepatocyte-Derived Liver Progenitor-Like Cells (HepLPCs).This study comprises a pre-clinical phase and an inaugural clinical trial involving nine cirrhosis patients to assess the feasibility and safety of HepLPC treatment.This investigator-initiated clinical study, generously funded by Shanghai Cryowise Technology Co., Ltd., marks a significant advancement in addressing the unmet medical needs of liver cirrhosis patients

The long-lasting influence of S protein on cerebrovascular function is unknown and should be investigated in future studies, especially considering the longevity of brain endothelial cells

However, our data showed that Gln deprivation did not induce apoptotic cell death within a short period of time, such as 24 h