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These mechanisms lead to the failure of traditional treatments, exacerbating the prolongation of treatment duration, the increase in mortality rate and the spread of drug-resistant bacteria

The final score which was less than 5 was defined as low expression and score more than 5 was defined as high expression

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In addition, supplementing the raw materials (cysteine, glycine, glutamate, and selenium) for synthesizing GSH or GPX to achieve an elevated GSH system in the myocardium is another feasible strategy

While this manuscript was in preparation, a different group independently reported the role of R08E5.3 in DTT resistance and isolated a group of 10 different mutations in the same methyltransferase gene [10]