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Clin Sci

It is key in supporting immune function, metabolism, forming sperm cells, tissue building and repair, and helping with certain enzyme functions

The findings highlight how cancer cells adapt to survive in nutrient-poor environments

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Regarding treatment strategies, it is suggested that the marked decrease in GPx1 expression may be the major mechanism of tumor sensitization to anthracyclines [93] and that GPx1 can partially inhibit doxorubicin-induced cell death-related signaling in breast cancer by interfering with the activation of the sphingomyelin-ceramide pathway [85]