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Goutman et al., 2022)

doi: 10.1111/jvim.15619 170 TamaiYIwasaMEguchiAShigefukuRSugimotoKHasegawaHet al

The observation that higher plasma concentrations of 2 can be achieved after oral delivery than for PZQ, coupled with the greater ex vivo potency of compound 2 , strongly suggest that further optimization will yield an orally bioavailable schistosomicidal agent that will be transformative in the clinical setting

However, this assumption may obscure the unique biological information inherent in each mode, thereby limiting the comprehensiveness of multi-omics analysis

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