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Additionally, patients on medications that affect liver enzymes, particularly those that are substrates, inhibitors, or inducers of cytochrome P450 enzymes, should be monitored for changes in drug efficacy or side effects, as glutathione may influence liver metabolism and thus the pharmacokinetics of these drugs

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For these reasons, this pathway was not recognized to be functional

92,93 The transamination product of Asp, asparagine (Asn), is more permeable than Asp, but when cellular asparaginase activity is inhibited, Asn cannot be converted to Asp

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