glutathione-responsive prodrug

glutathione-responsive prodrug GSH-triggered drug release and the responsive mechanism of Emerging Strategies in Stimuli-Responsive Prodrug

Name: glutathione-responsive prodrug GSH-triggered drug release and the responsive mechanism of Emerging Strategies in Stimuli-Responsive Prodrug
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Emerging Strategies in Stimuli Responsive Prodrug Nanosystems for Cancer Therapy ACS Nano PDF) Glutathione responsive iNOS inhibiting polymeric prodrug for targeted Inhibition of angiogenesis Construction of glutathione responsive paclitaxel prodrug nanoparticles for image guided targeted delivery and breast cancer therapy RSC Advances (RSC Publishing) DOI:10.1039 D4RA00610K Glutathione Responsive Prodrug Nanoparticles for Effective Drug Delivery and Cancer Therapy ACS Nano A GSH Activatable Theranostic Prodrug Based on Photoinduced Electron Transfer for Cancer Fluorescence Imaging and Therapy

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Description

Science 330 (6009), 13401344

Taking advantage of the fact that they can be reduced by thiols that exist in the cell cytoplasm, such as glutathione, ADCs have been engineered to be conjugated to the disulfide linkers that remain stable in the circulation and selectively release drugs in the cytoplasm