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An increase in liver PPARgamma2 is an initial event to induce fatty liver in response to a diet high in butter: PPARgamma2 knockdown improves fatty liver induced by high-saturated fat

Laboratory studies use these receptor systems to investigate peptide mediated signaling pathways involved in neuroendocrine communication, nutrient sensing, and metabolic regulation within experimental models

Fecal microbiota transplantation improves metabolism and gut microbiome composition in db/db mice

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Similarly, berberine, an isoquinoline alkaloid, has shown profound regulatory effects on gut microbiota in multiple experimental models of GI inflammation