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BMC Urol 2020

Toxins 14 (5), 344

Activation of STING leads to TBK1 and IRF3 phosphorylation, inducing interferons and many interferon-stimulated genes, as well as NF-B activation (49, 50).Notably, circulating mtDNA in surgical patients has been correlated with STING pathway activation markers and with endothelial dysfunction (51, 52)

Similar results were obtained in previous reports for mushroom tyrosinase, with values for KA inhibition on monophenols and diphenols of 5.7 and 30.1 M, respectively 30,31 , and the value for HQ inhibition on monophenols of 33.5 M 32