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Oxidative stress impairs oocyte quality and melatonin protects oocytes from free radical damage and improves fertilization rate

This review integrates mechanistic insights with translational advances, outlining how dysregulation of chaperones, autophagy-mitophagy, the ubiquitinproteasome system, and ER stress pathways drive human diseases, while highlighting emerging therapeutic platforms, from pharmacological chaperones and autophagy modulators to targeted protein degradation technologies, CRISPR screens, spatial biology, and AI-guided drug discovery

Metagenome-wide association of microbial determinants of host phenotype in Drosophila melanogaster

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