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Furthermore, SF3B1 mutations can lead to the production of a longer isoform of interleukin-1 receptor-associated kinase 4 (IRAK4), further enhancing NF-B activation (115)

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In contrast, other reports have shown that AMPK mediates dopaminergic cell death induced by 6-hydroxydopamine (6-OHDA) and mitochondrial toxins as well [73,74]

This suggests that there is some component in the ELF or lung that can act as a sensor to titrate the increase in GSH levels to prevent the ELF GSH level from dropping below basal levels