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Description

PLoS ONE 17 , e0274116 (2022)

The homogenous activity profile of our TXNRD1 inhibitors is especially notable compared to (1S,3R)-RSL3 (RSL3) and the selective nitroisoxazole-GPX4 inhibitor ML210 18 , all of which exhibit a more variable response pattern, independent of the cells ASCL1/REST or NEUROD1/REST status (Fig