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This approach involves three sequential steps: initially, the efficient removal of pathogens (Remove), followed by the remodeling of the infected microenvironment (Remodel), and ultimately, the repair of damaged organs (Repair)

Under copper stress, impaired DHAR expression substantially decreases the ASC/DHA ratio and blocks the MAPK signaling pathway, in order to cope with copper stress (Rodrguez-Rojas et al., 2019)