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The ferroptosis inducers include inhibitors targeting system Xc - (sorafenib) [55] and GPX4 (RSL3) [56], with ability to induce the accumulation of lipid peroxides [57], and directly suppressing GCL (L-buthionine sulfoximine, BSO) leading to GSH depletion [58]

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Isothiocyanates and synthetic OSC derivatives are more chemically stable and could persist longer, raising concerns regarding selective pressure on environmental resistomes if concentrations exceed ecological no-effect thresholds (Hu et al., 2025